1190197-97-7
- Product Number：22012341116
- Product Title：1190197-97-7
- Product Specification：
- Product Remark：
- Product Class：LIPIDS
- Product Order
| Biological target: | DLin-KC2-DMA is a cationic lipid for siRNA delivery. |
| In vitro activity: | In vitro screening studies using a panel of cationic lipids showed that LNPs (liquid nanoparticles) containing the ionizable cationic lipid 2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane (DLin-KC2-DMA) exhibited the most potent AR (androgen receptor) silencing effects in LNCaP cells. This is attributed to an optimized ability of DLin-KC2-DMA-containing LNP to be taken up into cells and to release the siRNA into the cell cytoplasm following endocytotic uptake. DLin-KC2-DMA LNPs were also effective in silencing the AR in a wild-type AR expressing cell line, LAPC-4, and a variant AR expressing cell line, CWR22Rv1. Reference: Int J Cancer. 2012 Sep 1;131(5):E781-90. https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.27361 |
| In vivo activity: | The ability of lipid nanoparticle (LNP) formulations of small-interfering RNA (siRNA) to silence AR (androgen receptor) was investigated in LNCaP xenograft tumors following intravenous (i.v.) injection. It was demonstrated that LNP AR-siRNA systems containing DLin-KC2-DMA can silence AR gene expression in distal LNCaP xenograft tumors and decrease serum PSA levels following i.v. injection. Reference: Int J Cancer. 2012 Sep 1;131(5):E781-90. https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.27361 |
Related CAS #: 1224373-32-3 (S-isomer) 1224373-36-7 (R-isomer) 1190197-97-7
Synonym: DLin-KC2-DMA; D-Lin-KC2-DMA; KC2;
IUPAC/Chemical Name: 2,2-dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane
InChi Key: LRFJOIPOPUJUMI-KWXKLSQISA-N
InChi Code: InChI=1S/C43H79NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-43(45-41-42(46-43)37-40-44(3)4)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,42H,5-12,17-18,23-41H2,1-4H3/b15-13-,16-14-,21-19-,22-20-
SMILES Code: CN(CCC1OC(CCCCCCCC/C=C\C/C=C\CCCCC)(CCCCCCCC/C=C\C/C=C\CCCCC)OC1)C
Appearance: Colorless to light yellow liquid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO and ethanol
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in ethanol or DMSO.
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
CATEGORIES
CATEGORIES
Name：Shanghai changyuhe pharmaceutical technology co., LTD
Website：http://www.changyuhe.com/
Phone：+86 13301875428
Contacts：Manager Mr Lu
E-mail: sales@changyuhe.com
QQ:542486614
Wechat：13301875428
